Product Description
| Product Name | Human 8-oxoguanine DNA Glycosylase (hOGG1) |
| Overview | Human 8-oxoguanine DNA glycosylase (hOGG1) is a key DNA repair enzyme that initiates the base excision repair (BER) pathway by recognizing and excising 8-oxoguanine (8-oxoG), a major mutagenic lesion resulting from oxidative DNA damage. hOGG1 specifically removes 8-oxoG paired with cytosine, preventing G:C to T:A transversions and maintaining genomic stability. In addition to its glycosylase activity, hOGG1 also possesses AP lyase activity, cleaving the DNA backbone at the abasic site generated after base removal. |
| Gene/Protein Names |
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| Molecular Weight | ~38 kDa (monomer) |
| Key Features |
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| Applications |
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| Source | Recombinant protein expressed in E. coli |
| Quality Control |
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| Formulation | 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, 10% glycerol, pH 7.5 |
| Storage | -80 °C (long-term); avoid repeated freeze-thaw cycles |
| References |
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