Lentivirus Pseudotyped with SARS-CoV-2 Spike Glycoprotein, United Kingdom Variant

Catalog #: EG-343
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Product Description
Product Name Lentivirus Pseudotyped with SARS-CoV-2 Spike Glycoprotein, HexaPro Variant, United Kingdom Variant
Catalog Number EG-343
Description Lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein (Wuhan-Hu-1, GenBank: QHD43416.1, United Kingdom variant, B.1.1.7), stabilized as a trimer (HexaPro variant) with mutations (RRAR682–685GSAS, F817P, A892P, A899P, A942P, K986P, V987P, N501Y) to maintain an antigenically optimal prefusion conformation, produced in HEK293T cells, purified by ultracentrifugation, expressing EGFP as a reporter.
Mutations RRAR682–685GSAS, F817P, A892P, A899P, A942P, K986P, V987P, N501Y
Source HEK293T cells
Reporter EGFP
Applications
  • Screening SARS-CoV-2 neutralizing antibodies
  • Assessing vaccine efficacy
Titer >1 × 107 RFU/mL or >1 × 105 TU/mL
Storage -80°C
Shipping Dry ice
References
  • Zost, S. J., et al. (2020). Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein. Scientific Reports, 10, 19076. doi:10.1038/s41598-020-76135-w.
  • Starr, T. N., et al. (2021). Prospective mapping of viral mutations that escape antibodies used to treat COVID-19. Science, 371(6531), 850–854. doi:10.1126/science.abf9302.
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