De Novo Protein / Binder Design

Generate target-conditioned proteins or binders with an evidence-gated design funnel. Available and commercially cleared RFdiffusion/RFantibody-family generation can be followed by ProteinMPNN or SolubleMPNN sequence design, fold and complex self-consistency, cognate-versus-decoy controls, interface geometry, aggregation/liability checks, and diversity-aware Pareto selection. Deliverables include exact FASTA, PDB models, design lineage, per-stage metrics, and reproducible provenance. Self-consistency and docking scores do not prove folding, binding, specificity, expression, or function. List price: $899. Final pricing depends on input size and scope — request a quote. Research use only; computational predictions require experimental validation. Methodology & tool catalog: https://nexteln.com/services/protein_design