3D Structure — Nanobody–Epitope Complex
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anti-TMPRSS2 protease nanobody complex
PDB 8S0N
■ nanobody (VHH) ■ antigen ■ epitope (45)
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Interactive model of the VHH bound to its structural epitope on TMPRSS2 protease (from experimental complex PDB 8S0N). Nanobody in blue, epitope contact residues in red. For research visualization.
Product Description
| Product Name | Anti-TMPRSS2 Nanobody (VHH), Recombinant, Purified |
| Description | A purified, engineered VHH nanobody against human TMPRSS2, a viral-entry protease and prostate-cancer marker. |
| Target / Specificity | Human transmembrane protease serine 2 (TMPRSS2) |
| Sequence | This nanobody is an engineered variant based on PDB 8S0N, with higher affinity and stability than the original published sequence. |
| Format | Purified recombinant single-domain antibody (VHH / nanobody), carrier-free |
| Tag & Expression | C-terminal 6×His tag; secreted from HEK293 cells and purified by one-step IMAC from the culture medium. |
| Molecular Weight | ~14 kDa (single VHH domain + His6; ~1/10 the size of a conventional IgG) |
| Purity | >90% by SDS-PAGE |
| Quantity | 100 µg |
| Formulation | PBS with 50% glycerol (carrier-free); 0.02% sodium azide |
| Applications | ELISA, IF, flow cytometry, protease-inhibition, viral-entry and prostate-cancer research |
| Structural Epitope | Epitope mapped from the experimental VHH–antigen complex (PDB 8S0N); 45 antigen contact residues within 5 Å. An interactive 3D complex model is shown on this page. |
| Storage | Store at -20°C; avoid repeated freeze-thaw. Stable 1 year. |
| Advantages | Nanobodies are the smallest functional antibody fragments: exceptional thermal and chemical stability, single-domain, high-yield recombinant production, and access to cryptic epitopes and dense tissue that conventional antibodies cannot reach. |
Product Documents
DatasheetEG-NB-TMPRSS201 Product Datasheet
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