3D Structure — Nanobody–Epitope Complex
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anti-HER2 (ERBB2) nanobody complex
PDB 5MY6
■ nanobody (VHH) ■ antigen ■ epitope (41)
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Interactive model of the VHH bound to its structural epitope on HER2 (ERBB2) (from experimental complex PDB 5MY6). Nanobody in blue, epitope contact residues in red. For research visualization.
Product Description
| Product Name | Anti-HER2 (ERBB2) Nanobody (VHH), Recombinant, Purified |
| Description | A purified, engineered VHH nanobody against human HER2 (ERBB2), a leading breast and gastric cancer target. The single-domain format penetrates tumor tissue for imaging and targeting research. |
| Target / Specificity | Human HER2 / ERBB2 (receptor tyrosine-protein kinase erbB-2) |
| Sequence | This nanobody is an engineered variant based on PDB 5MY6, with higher affinity and stability than the original published sequence. |
| Format | Purified recombinant single-domain antibody (VHH / nanobody), carrier-free |
| Tag & Expression | C-terminal 6×His tag; secreted from HEK293 cells and purified by one-step IMAC from the culture medium. |
| Molecular Weight | ~14 kDa (single VHH domain + His6; ~1/10 the size of a conventional IgG) |
| Purity | >90% by SDS-PAGE |
| Quantity | 100 µg |
| Formulation | PBS with 50% glycerol (carrier-free); 0.02% sodium azide |
| Applications | Flow cytometry, IF, IP, ELISA, tumor-targeting and HER2+ breast/gastric cancer research |
| Structural Epitope | Epitope mapped from the experimental VHH–antigen complex (PDB 5MY6); 41 antigen contact residues within 5 Å. An interactive 3D complex model is shown on this page. |
| Storage | Store at -20°C; avoid repeated freeze-thaw. Stable 1 year. |
| Advantages | Nanobodies are the smallest functional antibody fragments: exceptional thermal and chemical stability, single-domain, high-yield recombinant production, and access to cryptic epitopes and dense tissue that conventional antibodies cannot reach. |
Product Documents
DatasheetEG-NB-HER201 Product Datasheet
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