3D Structure — Nanobody–Epitope Complex
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anti-Hen Egg Lysozyme (HEL) nanobody complex
PDB 1JTO
■ nanobody (VHH) ■ antigen ■ epitope (28)
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Interactive model of the VHH bound to its structural epitope on Hen Egg Lysozyme (HEL) (from experimental complex PDB 1JTO). Nanobody in blue, epitope contact residues in red. For research visualization.
Product Description
| Product Name | Anti-Lysozyme (HEL) Nanobody (VHH), Recombinant, Purified |
| Description | A purified, engineered VHH nanobody against hen egg-white lysozyme (HEL) — the classic model antigen. An economical, robust positive control and assay-development reagent. |
| Target / Specificity | Hen egg-white lysozyme (HEL) |
| Sequence | This nanobody is an engineered variant based on PDB 1JTO, with higher affinity and stability than the original published sequence. |
| Format | Purified recombinant single-domain antibody (VHH / nanobody), carrier-free |
| Tag & Expression | C-terminal 6×His tag; secreted from HEK293 cells and purified by one-step IMAC from the culture medium. |
| Molecular Weight | ~14 kDa (single VHH domain + His6; ~1/10 the size of a conventional IgG) |
| Purity | >90% by SDS-PAGE |
| Quantity | 100 µg |
| Formulation | PBS with 50% glycerol (carrier-free); 0.02% sodium azide |
| Applications | ELISA, WB, affinity capture; ideal positive-control and assay-development reagent |
| Structural Epitope | Epitope mapped from the experimental VHH–antigen complex (PDB 1JTO); 28 antigen contact residues within 5 Å. An interactive 3D complex model is shown on this page. |
| Storage | Store at -20°C; avoid repeated freeze-thaw. Stable 1 year. |
| Advantages | Nanobodies are the smallest functional antibody fragments: exceptional thermal and chemical stability, single-domain, high-yield recombinant production, and access to cryptic epitopes and dense tissue that conventional antibodies cannot reach. |
Product Documents
DatasheetEG-NB-LYZ01 Product Datasheet
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