3D Structure — Nanobody–Epitope Complex
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anti-Complement C4 nanobody complex
PDB 7B2M
■ nanobody (VHH) ■ antigen ■ epitope (24)
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Interactive model of the VHH bound to its structural epitope on Complement C4 (from experimental complex PDB 7B2M). Nanobody in blue, epitope contact residues in red. For research visualization.
Product Description
| Product Name | Anti-Complement C4 Nanobody (VHH), Recombinant, Purified |
| Description | A purified, engineered VHH nanobody against human complement C4 for complement-pathway and autoimmune-disease research. |
| Target / Specificity | Human complement component C4 (alpha chain) |
| Sequence | This nanobody is an engineered variant based on PDB 7B2M, with higher affinity and stability than the original published sequence. |
| Format | Purified recombinant single-domain antibody (VHH / nanobody), carrier-free |
| Tag & Expression | C-terminal 6×His tag; secreted from HEK293 cells and purified by one-step IMAC from the culture medium. |
| Molecular Weight | ~14 kDa (single VHH domain + His6; ~1/10 the size of a conventional IgG) |
| Purity | >90% by SDS-PAGE |
| Quantity | 100 µg |
| Formulation | PBS with 50% glycerol (carrier-free); 0.02% sodium azide |
| Applications | ELISA, WB, IF, complement-pathway and autoimmune research |
| Structural Epitope | Epitope mapped from the experimental VHH–antigen complex (PDB 7B2M); 24 antigen contact residues within 5 Å. An interactive 3D complex model is shown on this page. |
| Storage | Store at -20°C; avoid repeated freeze-thaw. Stable 1 year. |
| Advantages | Nanobodies are the smallest functional antibody fragments: exceptional thermal and chemical stability, single-domain, high-yield recombinant production, and access to cryptic epitopes and dense tissue that conventional antibodies cannot reach. |
Product Documents
DatasheetEG-NB-C401 Product Datasheet
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